Cyclosporine in cats - Dosage, uses and side effects

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In this AnimalWised article we will talk about cyclosporine for cats, a drug known for its anti-inflammatory effect which is used to combat different pathologies. But you have to know that it will also act on the immune system, so it is essential that we only administer it with a veterinary prescription.

Next, we will explain what the Uses of Cyclosporine in Cats, how this medicine should be given, in which copies it is not suitable and, above all, what side effects we have to be aware of.

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  1. What is cyclosporine?
  2. What is cyclosporine for in cats?
  3. Cyclosporine dosage in cats
  4. Contraindications of cyclosporine in cats
  5. Side effects of cyclosporine in cats

What is cyclosporine?

Cyclosporine is a drug that is included in the group of immunomodulatory agents, by having the ability to influence the immune system, increasing or decreasing its response. It has a selective immunosuppressive effect, since it affects, in particular, T lymphocytes, cells that are formed in the bone marrow and belong to the immune system.

Cyclosporine in cats has a anti-inflammatory and antipruritic effect. It influences the production of different substances that are associated with inflammation, hence the effect it achieves. This action is relatively rapid, since, even in fasting oral administration, it reaches the maximum concentration in the blood within 1-2 hours. It is metabolized in the liver.

What is cyclosporine for in cats?

Cyclosporine is often used to treat a condition known as chronic allergic dermatitis. This pathology usually presents with itching, inflammation of the skin, irritation especially in the head and neck, symmetrical hair loss, etc., signs that may be compatible with other skin diseases, for example parasitosis, infections, food allergies, among other That is why it is essential that the veterinarian diagnose and determine the need to administer cyclosporine and we do not think of medicating our cat on our own. In addition, it should be known that it is common for cyclosporine to be only one of the tools to treat the clinical picture, so the veterinarian will have to guide other drugs and different management measures, especially to relieve the itching that is associated with it. pathology.

There are other indications for the use of cyclosporine in cats related to its anti-inflammatory function, such as the following:

  • hives
  • asthma
  • granulomas
  • stomatitis
  • certain eye disorders
  • inflammatory bowel disease
  • autoimmune hemolytic anemia

Likewise, only the veterinarian may prescribe its use..

Cyclosporine dosage in cats

To calculate the dose of cyclosporine for cats, it is essential to accurately determine the weight of the cat. Some are recommended 7 mg for every kg of weight to be administered once a day, at least as a starter treatment, but the dose varies depending on the disease to be treated. The idea is to gradually reduce this frequency as the cat evolves, but you have to know that they are usually long treatments, lasting several weeks, before being able to give it every two, three or even four days. It is an assessment that is left to the discretion of the veterinarian. It must be borne in mind that, on occasions, the cat relapses and it is necessary to start over with the daily treatment.

Cyclosporine is usually found in oral solution and administered directly into the mouth or mixed with food in a very small amount to ensure that the cat ingests the entire dose. There is also its transdermal administration, but it is not recommended in cats because the absorption is lower. In addition, cyclosporine is found in eye drops For use in eye conditions, so there is not only atopic cyclosporine for cats, we also have ophthalmic cyclosporine for cats.

Contraindications of cyclosporine in cats

Not all cats will be able to take advantage of the benefits of cyclosporine. There are some cases in which this drug is not indicated. We highlight the following:

  • Copies that at some point have stated allergy to this active ingredient or we suspect they may be hypersensitive.
  • Leukemia sufferers or immunodeficiency. If this information is unknown, the cat should be tested before giving cyclosporine..
  • Diabetics.
  • Kittens with less than two months old.
  • Cats that do not reach 2.3 kg in weight, except for the exceptions decided by the veterinarian.
  • In pregnant or lactating cats It is also at the discretion of the veterinarian after assessing the risks and benefits of its use, since there are no studies on the safety of cyclosporine in these situations. The possibility has been seen that it crosses the placental barrier and is excreted in milk.
  • Cats that have received a vaccine in the previous two weeks. On the other hand, vaccines should not be given while the treatment with cyclosporine or within two weeks after finishing it. Cyclosporine interferes with the effectiveness of vaccination.
  • Finally, if the cat is being treated with some other drug, the veterinarian will have to assess possible interactions.

Side effects of cyclosporine in cats

Cyclosporine inhibits T lymphocytes. This fact is related to a increased incidence of malignant tumors because it decreases the body's response capacity. For this reason, it is not only important that we do not think of giving cyclosporine to the cat without having the veterinarian, but this same professional must very well assess the advantages and benefits of prescribing it. If you decide to use it, the cat should be monitored very well and consult immediately if any enlarged lymph nodes are observed..

In addition, if the cat is toxoplasmosis negative and becomes infected during treatment with cyclosporine, it can develop the disease, even severely. To avoid this, it is recommended to prevent him from accessing the outside and not allowing him to eat meat or raw prey while the treatment lasts. On the other hand, the cat could present Adverse effects, more or less frequent, such as the following:

  • Digestive problems, especially vomiting and diarrhea.
  • Increased appetite.
  • Lethargy.
  • Hypersalivation.
  • Hyperactivity.
  • Gingival hyperplasia, which is an increase in the size of the gums.
  • Signs consistent with diabetes, such as increased urine output or water intake.
  • Weight loss and decreased appetite. If this is the case of our cat, it must be weighed regularly to avoid excessive weight loss that could lead to health problems..

Some of these effects can resolve themselves without having to suspend treatment, but in other cases it will be necessary to suppress it or, at least, modify it. Therefore, you have to go to the vet.

This article is merely informative, at we do not have the power to prescribe veterinary treatments or make any type of diagnosis. We invite you to take your pet to the vet in the event that it presents any type of condition or discomfort.

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